威尼斯城娱乐官方平台,威尼斯城真人赌钱网站

医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是威尼斯城真人赌钱网站六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759364
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵章晓联李红良卿国良
百千万人才工程选者: 舒红兵、黄从新章晓联?
万人计划: 领军人才:舒红兵唐其柱李红良 ? 青年拔尖人才: 刘天罡?、
王连荣王培刚 ? ? ? ? ?
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教育部新世纪优秀人才: 章晓联、何小华乐江、 于红刚 李雁郑芳、
胡锦跃、 黄鹤、李红良、 张 旗、 叶晓茜、 尚政军、 郭继华、 张玉峰、
周海兵、 刘天罡、 王连荣、 瞿旭东、洪 葵

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姓名:刘天罡

单位:威尼斯城真人赌钱网站药学院

职称:教授、博导

邮箱:liutg@whu.edu.cn

联系电话:+86-27-68755086

研究方向:

1.改造微生物代谢途径生产新型生物燃料和高附加值化工原料

2.利用合成生物学生产稀有来源药物和药物前体

3.利用组合生物学生产新型抗肿瘤药物

 









代表性论著:

1.Bian G, Deng Z, Liu T. 2017. Strategies for terpenoid overproduction and new terpenoid discovery. Current Opinion in Biotechnology, 48:234–241.

2.Bian G, Han Y, Hou A, Yuan Y, Liu X, Deng Z, Liu T. 2017. Releasing the potential power of terpene synthases by a robust precursor supply platform. Metabolic Engineering, 42:1-8.

3.Tan G, Deng K, Liu X, Tao H, Chang Y, Chen J, Chen K, Sheng Z, Deng Z, Liu T. 2017. Heterologous Biosynthesis of Spinosad: An Omics-Guided Large Polyketide Synthase Gene Cluster Reconstitution in Streptomyces. ACS Synthetic Biology, 6(6):995-1005

4.Bian G, Yuan Y, Tao H, Shi X, Zhong X, Han Y, Fu S, Fang C, Deng Z, Liu T. 2017. Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6. BIOTECHNOL J, 12(4).

5.Liu Z, Zhang Y, Jia X, Hu M, Deng Z, Xu Y, Liu T. 2017. In Vitro Reconstitution and Optimization of the Entire Pathway to Convert Glucose into Fatty Acid. ACS Synth. Biol. 6(4):701-709(共通讯编辑)

6.Tan G, Liu T. 2017. Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria. Metabolic Engineering, 39: 228-236.

7.Huang M, Deng ZX, Tian J, Liu T. 2017. Synthesis and biological evaluation of salinomycin triazole analogues as anticancer agents. European Journal of Medicinal Chemistry. 127:900-908.(共通讯编辑)

8.Liu Z, Liu T. 2016. Production of acrylic acid and propionic acid by constructing a portion of the 3?hydroxypropionate/4?hydroxybutyrate cycle from Metallosphaera sedula in Escherichia coli. J Ind Microbiol Biotechnol. 43:1659-1670

9.Hou A, Deng Z, Ma H, Liu T. 2016. Substrate screening of amino transaminase for the synthesis of a sitagliptin intermediate. Tetrahedron. 72(31):4660-4664(共通讯编辑)

10.Ye Z, Li X, Cheng Y, Liu Z, Tan G, Zhu F,  Fu A, Deng Z, Liu T. 2016. Evaluation of 3?hydroxypropionate biosynthesis in vitro by partial introduction of the 3?hydroxypropionate/4?hydroxybutyrate cycle from Metallosphaera sedula. J Ind Microbiol Biotechnol 43:1313-321.

11.Ma T, Zhou Y, Li X, Zhu F, Cheng Y, Li Y, Deng Z, Liu T. 2016. Genome mining of astaxanthin biosynthetic genes from Sphingomonas sp. ATCC 55669 for heterologous overproduction in E. coli. BIOTECHNOL J. 2016, 11, 228–237

12.Ma T, Deng Z, Liu T. 2016. Microbial production strategies and applications of lycopene and other terpenoids. World Journal of Microbiology and Biotechnology. 32, 15.

13.Liu Q, Wu K, Lu L, Cheng Y, Zhang Y, Deng Z, Liu T. 2015. Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction. Metabolic Engineering. 28, 82-90.

14.Zhu F, Lu L, Fu S, Zhong X, Hu M, Deng Z, Liu T. 2015. Targeted engineering and up of lycopene overproduction in Escherichia coli. Process Biochemistry. 50, 341-346.

15.Tao H, Guo D, Zhang Y, Deng Z, Liu T. 2015. Metabolic engineering of microbes for branched-chain biodiesel production with low-temperature property. Biotechnology for Biofuels. 8:92.

16.Li X, Guo D, Cheng Y, Zhu F, Deng Z & Liu T. 2014. Overproduction of fatty acids in engineered Saccharomyces cerevisiae. Biotechnology and Bioengineering, 111(9), 1841-1852

17.Zhu F, Zhong X, Hu M, Deng Z & Liu T. 2014. In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli. Biotechnology and Bioengineering, 111(7), 1396-1405

18.Liu R, Zhu F, Lu L, Fu A, Lu J, Deng Z & Liu T. 2014. Metabolic engineering of fatty acyl-ACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli. Metabolic Engineering, 22, 10-21.

19.Guo D, Zhu J, Deng Z & Liu T. 2014. Metabolic Engineering of Escherichia coli for Production of Fatty Acid Short-Chain Esters through Combination of the Fatty Acid and 2-Keto Acid Pathways. Metabolic Engineering, 22, 69-75.

20.Yu X, Liu T, Zhu F, Khosla C. 2011.In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli. Proc Natl Acad Sci U S A. 108(46):18643-8.(共通讯编辑,共第一编辑)


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教育部 国家卫生健康委员会 省教育厅 省卫生健康委 威尼斯城真人赌钱网站 校图书馆
基础医学院 第一临床学院(人民医院) 第二临床学院(中南医院) 口腔医学院(口腔医院) 药学院 健康学院 医学研究院 医学职业技术学院 动物实验中心和ABSL-Ⅲ实验室 亚心临床学院(亚洲心脏病医院) 同仁临床学院(同仁医院) 武汉总医院临床学院(广州军区武汉总医院) 恩施临床学院(恩施州中心医院) 医学部附属中山医院
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